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London School of Hygiene & Tropical Medicine Malaria Centre

Malaria research in vector studies

Investigating novel indoor delivery systems for insecticides against malaria vectors.

LSHTM investigators:
Corine Ngufor, Raphael N’Guessan & Mark Rowland.
External collaborators:
Patrick Tungu (National Institute for Medical Research, Tanzania); Benjamin Koudou (Centre Suisse de Recherche Scientifique, Cote D’Ivoire); Sagnon N’Fale (Centre National de Recherche et de Formation sur le Paludisme, Burkina Faso).
Funding body:
The European Union Seventh Research Framework Programme through the AvecNet Consortium.

Despite the considerable increase in donor funding to support the global drive towards malaria elimination, it is unlikely that IRS due to its associated operational and logistic constraints would be scaled-up to satisfactory levels to effectively interrupt transmission in holoendemic areas in sub-Saharan Africa.

Alternative effective tools for delivering insecticides in doors which can be deployed either as single interventions or to complement LLINs need to be urgently investigated and developed.

The aim of this study is to evaluate plastic wall linings and net wall hangings treated with the organophosphate pirimiphos methyl as novel malaria vector control tools. Insecticide treated plastic sheeting and net wall hangings can be likened to a long-lasting IRS treatment and also have the advantage of providing a more uniform covering of the wall with insecticide compared to IRS and of improving interior appearance of traditional dwellings.  Their potential to provide improved vector control and/or manage insecticide resistance when deployed to complement LLINs in a combination approach will also be investigated.

Experimental hut trials are being carried out in 3 malaria endemic areas in Sub-Saharan Africa including Muheza-Tanzania where the vectors are largely susceptible to insecticides, Valley du Kou-Burkina Faso where the vectors are very resistant to pyrethroids but susceptible to organophospates and Tiassales-Cote D’Ivoire where pyrethroid and organophosphate resistance co-exist.