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London School of Hygiene & Tropical Medicine Malaria Centre

Malaria research in vector studies

Pan African Malaria Vector Research Consortium (PAMVERC).

LSHTM investigators:
Richard Oxborough & Mark Rowland.
External collaborators:
Franklin Mosha (Kilimanjaro Christian Medical University College, Tanzania)
Funding body:
The Bill & Melinda Gates Foundation through the Innovative Vector Control Consortium.

The London School of Hygiene and Tropical Medicine in partnership with Kilimanjaro Christian Medical University College conducted a series of insecticide evaluations of new products for malaria vector control.

Pyrethroids are the only group of insecticides approved by World Health Organization for treating mosquito nets (ITN) and have also been preferred for indoor residual spraying (IRS) in Africa in recent years. Consequently, pyrethroid resistance has become widespread in malaria vectors across Africa. For continued effectiveness of malaria control programs it is imperative to develop new formulations of insecticides for ITN and IRS.

A series of trials were done in collaboration with several major chemical manufacturers including BASF, Bayer, DuPont, Sumitomo and Syngenta. Trials have focused on Phase 1 laboratory and Phase 2 experimental hut evaluation of novel products for the control of pyrethroid resistant mosquito populations.

Several novel long-lasting or wash resistant formulations have produced promising results and data has been submitted to the World Health Organization Pesticide Evaluation Scheme as part of product registration.

There is still a major dearth of public health insecticides and in future we will continue evaluating promising new products at all stages from laboratory to community testing, as well as investigating resistance management strategies.

We expect that some of the products we have evaluated will be used for widespread malaria vector control in Africa within the next few years.