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London School of Hygiene & Tropical Medicine Malaria Centre

Malaria research in drug development, deployment and resistance

Tracking Resistance to Artemisinins Collaboration (TRAC)

LSHTM investigators:
Shunmay Yeung, Colin Sutherland, Phillipe Guyant & Richard Coker.
External collaborators:
Rick Fairhurst (National Institutes of Health, USA); Pharath Lim & Yi Poravuth (Cambodian National Malaria Centre, Cambodia); Mayfong Mayxay (Wellcome Trust-Mahosot Hospital-Oxford Tropical Medicine, Laos); Francois Nosten (Shoklo-Malaria Research Unit, Thailand); Sasithon Pukrittanyakamee, (Mahidol University, Thailand); Abdul Faiz (Chittagong Medical College, Bangladesh); Olubenga Mokuolu (University of Ilorin, Nigeria); Neena Valecha (India); Steffan Boramman (KEMRI- Wellcome Trust Research programme Research Collaboration, Kenya); Ye Htut (Department of Medical Research, Myanmar); Tran Tinh Hien (Oxford University Clinical Research Unit, Vietnam).
Funding body:
UK Department for International Development.

The Tracking Resistance to Artemisinin Collaboration (TRAC) is a multi-country multi-disciplinary collaboration is led by the Mahidol-Oxford Research Unit (MORU) that was formed to inform artemisinin resistance containment efforts in response to a call for proposals by the UK Government Department for International Development (DfID).

The initiative is funded for three years and has three main components:

  1. Clinical. A multicentre clinical trial at 15 sites in 9 countries predominantly in Asia, to detect evidence of spread of artemisinin resistance. This work is co-ordinated by the Mahidol Oxford Tropical Medicine Research Unit in Bangkok with the support of WWARN and involves molecular and pharmacokinetic studies.
  2. Understanding demand factors. This component led by LSHTM focuses on social  and economic research including the demand, use and quality of drugs, by at-risk populations and the implications for the development and control of drug resistance using mixed methods.  It is closely linked to the clinical studies in Cambodia, Thailand, Laos, Bangladesh and Nigeria,  with additional operational research being conducted in Cambodia including supporting and the vector control studies.
  3. Vector control. Researchers from the Liverpool School of Tropical School of Tropical Medicine plan to produce and evaluate innovative vector control strategies developed specifically to suit the Cambodian context.

The Global Malaria Programme of the World Health Organisation is another key partner and will review results generated by the 3 research arms.