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London School of Hygiene & Tropical Medicine Malaria Centre

Malaria clinical trials and studies

Dihydroartemisinin-piperaquine for Seasonal Malaria Chemoprevention (SMC) in African children: efficacy, safety, tolerability and pharmacokinetics.

LSHTM investigators:
Issaka Zongo, Brian Greenwood, Daniel Chandramohan, Colin Sutherland & Paul Mlligan.
External collaborators:
Francois Nosten (Nuffield Department of Clinical Medicine, UK); Jean Bosco Ouedrago (Institut de Recherche en Sciences de la Santé, Burkino Faso), Philip Rosenthal (University of California, USA).
Funding body:
Holley Cotec.

The aim of this study is to compare the safety, tolerability and efficacy of DHA-PQ with SP-AQ when used for seasonal IPT in children. The trial took place in Lena district near Bobo-Dioulasso.

1500 children were randomized to receive SMC with one or other regimen and, outside the trial, a cohort of untreated children was followed to determine malaria incidence without SMC. Four finger prick blood samples were taken each month from a subset of children for measurement of piperaquine concentrations and venous samples were taken from a second subset each month to measure the effect of SMC doses on haematological and biochemical parameters.