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Malaria clinical trials and studies
Childhood Febrile Illness Treatment Study (C-FIT ).
In late 2010 WHO guidelines abandoned the policy of presumptive treatment of malaria in favour of treatment guided by a blood slide or malaria rapid diagnostic test (RDT).
However, there is limited evidence of the safety of this policy in routine outpatient settings in Africa.
In a malaria endemic area of Tanzania 965 children with a non-severe febrile illness were enrolled, and treatment for malaria was determined by the results of a clinical examination and RDT result, and blood culture and serum lactate were also collected. RDT-negative children were followed up over 14 days.
Overall, 158 (16.4%) were RDT-positive and treated with artemether-lumefantrine and 807 (83.4%) were RDT-negative and treated with non-anti-malarial medicines. Compared with RDT-positives, RDT-negative children were on average younger with a lower axillary