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London School of Hygiene & Tropical Medicine Malaria Centre

EVIMalaR Welcomes New Affilliates

 
Image: Survey with parents in the Philippines. Image courtesy of Dalia Iskander
 

Image: Survey with parents in the Philippines. Image courtesy of Dalia Iskander

11 November 2013
Malaria Centre members David Conway and Taane Clark selected to join EVIMalaR Network

EVIMalaR is a joint research FP7 Network of Excellence, funded by the European Commission and currently involving 62 partners from 51 institutes in Europe, Africa, India and Australia (coordinated at the University of Glasgow, Scotland, UK). It seeks to integrate malaria research that is directed towards a better understanding of the basic knowledge of the parasite, its vector and of the biology of the interactions between the parasite and both its mammalian host and vectors.

In June 2013, the EVIMalaR Consortium issued a call for Affiliates, welcoming applications from European scientific teams interested in conducting collaborative research. Taane Clarke and David Conway were selected to joint the network

David Conway and his group will be working in the area of vector-parasite interactions in the following research themes: 

Parasite population genomics. We undertake research to identify signatures of natural selection on malaria parasites, particularly those driven by interaction with human and mosquito hosts. To provide a framework for this, we also study the population genetic structure of P. falciparum in areas of differing endemicity. Our work on the P. knowlesi zoonosis now focuses on population genetic and genomic analyses. We occasionally contribute to studies of vector population genetics. 

Erythrocyte invasion by parasites. We study the importance of alternative receptors for erythrocyte invasion by P. falciparum clinical isolates, undertaking culture phenotyping and expression profiling of parasites. We are attempting to use receptor knockdown, and flow cytometric cell sorting for improved phenotyping and cloning.

Immune responses to parasites. We study naturally acquired immune responses and their targets in the malaria parasite, identifying particular merozoite antigens as potential components for a vaccine. We also study determinants of the duration and isotype profile of antibody responses.