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London School of Hygiene & Tropical Medicine Malaria Centre

Seminar | Rapid, iterative and scalable genome editing in P. knowlesi : from basic science to vaccine design

25 October 2017 at 12.30 pm
Lucas Room – LG81
IID Seminar


CRISPR Cas9 genome editing has revolutionised many fields of research, including through its recent application to P. falciparum. We have now adapted the system for use in the zoonotic malaria parasite P. knowlesi and adopted innovative approaches for construct generation which enables fast, markerless and scalable modification of the genome. This has allowed us to investigate parasite biology in new and ambitious ways including helping us develop tools to understand parasite invasion and also using P. knowlesi as a surrogate to test potential vaccines against P. vivax - an important malaria pathogen which cannot be maintained in culture.


Speaker: Dr Rob Moon, LSHTM

Date: 25 October 2017 

Time: 12.30 pm

Venue: Lucas Room – LG81